| Characteristic | Details |
|---|---|
| Active Ingredient | Cabergoline 0.5mg |
| Form | Oral Tablet |
| Packaging | Blister pack of 8 tablets |
| Storage Conditions | Below 25°C, away from moisture |
| Learn More about Dostinex | |
Pharmacokinetics
Dostinex, also known as Cabergoline 0.5mg, falls under the dopamine receptor agonist class. It primarily acts on D2 receptors, leading to its clinical effects. The oral bioavailability of Cabergoline is noteworthy. It is swiftly absorbed, peaking in plasma within 2-3 hours post-ingestion. The half-life extends to around 63-69 hours, marking its sustained action.
Metabolism occurs predominantly in the liver. Cabergoline undergoes hydrolysis to inactive compounds. Excretion is primarily via feces, with a minor portion in urine. The pharmacokinetic profile supports once or twice weekly dosing, maximizing patient compliance. Its lipophilic nature ensures efficient penetration across tissues, potentiating its effects.
Areas of Use
Dostinex 0.5mg finds usage in multiple clinical scenarios. Its main indication is the treatment of hyperprolactinemia. By reducing prolactin levels, it alleviates associated symptoms such as amenorrhea, galactorrhea, and infertility. It is also beneficial in Parkinson’s disease management, leveraging its dopamine agonistic properties.
Additionally, it shows promise in treating acromegaly. Here, it complements somatostatin analogs to suppress growth hormone secretion. In pituitary tumors, it aids in tumor size reduction. Dostinex’s versatility extends to managing prolactinomas, providing symptomatic relief and tumor control.
Dostinex Contraindications
Contraindications for Dostinex 0.5mg are critical to note. Patients with uncontrolled hypertension should avoid it due to potential exacerbation. Cardiac valvulopathy history necessitates caution, given Cabergoline’s valve-affecting propensity.
Hypersensitivity to ergot derivatives or any component precludes its use. In pregnancy, its safety profile remains undetermined; thus, it is typically contraindicated. Lactating women should refrain from use, as it can suppress lactation.
Dostinex Storage
Proper storage of Dostinex ensures its efficacy. Keep the tablets below 25°C. Avoid areas with excessive moisture. Retain them in their original blister packaging to maintain integrity.
Store in a dry place, away from direct sunlight. Ensure they are out of children’s reach. Adhering to these guidelines preserves the drug’s potency.
Dostinex Signs and Symptoms of Overdose
Recognizing overdose symptoms of Cabergoline 0.5mg is crucial. Patients may experience nausea, vomiting, and dizziness. Extreme cases could lead to psychotic episodes due to dopamine excess.
Orthostatic hypotension and confusion may occur. Immediate medical intervention is necessary. Activated charcoal can limit absorption if administered promptly.
Is Non-prescription Dostinex Available?
Dostinex 0.5mg is not available over-the-counter. It requires a medical prescription. Its potent pharmacological actions mandate professional oversight.
Obtaining it without prescription risks misuse and adverse effects. Consultation with a healthcare provider ensures appropriate dosing and monitoring.
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